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IP Indian Journal of Immunology and Respiratory Medicine

A study of pulmonary function tests in HIV infected children

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Author Details: G.P. Vignan Kumar

Volume : 3

Issue : 1

Online ISSN : 2581-4222

Print ISSN : 2581-4214

Article First Page : 21

Article End Page : 23


Background: If untreated, HIV mortality will be high from the cause of acute respiratory infections in neonatal stage up to one year of age. Here, the study was conducted to determine the prevalence of spirometric abnormalities in HIV positive children.
Methodology: A cohort of 20 children in the age group of 10 to18 years with a diagnosis of HIV was included. Spirometry measurements carried out to analyze the forced expiratory volume at one second (FEV1), forced vital capacity (FVC), FVC/FEV1 ratio, and forced expiratory flow 25% to 75% (FEF25-75) and pulse oximetry. The PFT data were analyzed in correlation with the age and blood parameters.
Results: 20 HIV-infected participants with a mean age 15.5 years were recruited. 17 children were on antiretroviral therapy. The mean CD4 count was 496±235.22 (151-1088) cells/µl. Mean Hb% value observed was 9.96±2.5 and mean total leucocyte count was 3785±2087.37. We found mean FEV1 as 71.05±9.2, mean FVC as 71.6±8.5 and ratio FEV1/FVC as 98%±0.11. The total lung capacity was observed as 73%-117%.
Conclusions: Clinicians evaluating HIV infected children with respiratory symptoms must first determine whether those symptoms are a result of common bacterial symptoms or opportunistic infections.

Keywords: Antiretroviral therapy (ART); Chronic lung disease; HIV; Pulmonoray function test.

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