IP International Journal of Medical Microbiology and Tropical Diseases


Role of Vesicular Trafficking in Infection and Cancer: A Review


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Author Details: Yogesh Kumar Negi, Harsh Kumar

Volume : 2

Issue : 1

Online ISSN : 2581-4761

Print ISSN : 2581-4753

Article First Page : 27

Article End Page : 30


Abstract

Most of the pathogenic bacteria and viruses are capable of causing variety of infections in the respective hosts. These infectious agents enter and spread inside the host cells via various modes most notable of which is endocytosis machinery. Several pathogenic strains of bacteria like Mycobacterium, Samlonella and viruses like Dengue virus and HIV-1 make use of endocytic trafficking of vesicles to invade the host cells, multiply and exit. Oncogenic mutations accumulate over the time and affect many vesicular trafficking components causing aberrant distribution of cell surface proteins and downstream signalling leading to reckless proliferation of cells. In this paper, we tried to analyse how pathogens exploit vesicular trafficking machinery of cells for their advantage in infection and perturbations in the process leads to neoplasia conditions. Identification of some key proteins participating in the function may lead to development of new anaphylactic or therapeutic interventions.

Key words:
Helicobacter, Endocytosis, Exocytosis, Metastasis, Mycobacterium, Neoplasia, RABs