IP International Journal of Medical Microbiology and Tropical Diseases


Isolation of Candida species from urine samples along with its antifungal susceptibility pattern in Paediatric patients attending Tertiary Care Hospital of Baroda


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Author Details: Hiral Kashanbhai Patel, Rachana Akash Bhavsar

Volume : 3

Issue : 1

Online ISSN : 2581-4761

Print ISSN : 2581-4753

Article First Page : 11

Article End Page : 15


Abstract

Background: The presence of yeast cells in urine is called Candiduria. It is an increasingly common finding in hospitalized patients.Candida albican is the most common causative agent of fungal infections. However, in recent years there has been an increasing trend in the emergence of non albicans candida as a potential pathogen which is found to be more resistant to antifungal drugs than Candida albicans. The main aim of this study is to identify & differentiate the Candida spp isolated from urine samples of Peadiatric patients along with their antifungal susceptibility pattern.
Material and Method: This study was conducted from April 2013 to September 2013 in Department of Microbiology, Medical College Baroda. A total 1202 urine samples were collected from Paediatric patients suspected of having urinary tract infections. Urine samples were processed by semi quantative culture method. Antifungal susceptibility of all the isolates was performed by the Modified Kirby Baur disc diffusion method with fluconazole, voriconazole.
Result: A total 57 Candida species were isolated from 427 culture positive urine samples. Candida albicans was most commonly isolated (24.50%) followed by Candida tropicalis (22.80%). Overall, 75% cases were due to non albican candidas species. All candida isolates were found to be susceptible to voriconazole but higher degree of resistance was seen with fluconazole.
Conclusion: Candida spp were the pathogens identified in 13% of hospital-acquired urinary tract infections in Peaditric patients. Non albicans candida species are replacing to Candida albicans as predominant pathogen causing nosocomial urinary tract infections. Candida glabrata and Candida krusei were more resistant to fluconazole, so it is necessary to use other antifungal drug to combat the infection caused by these species.

Keywords:
Candiduria, Voriconazole, Fluconazole, Candida albican