Indian Journal of Microbiology Research


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Author Details: Vijay N. Charde, Shweta M. Bhiwankar, Pratik M. Bezalwar

Volume : 1

Issue : 1

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 4

Article End Page : 13


Background: Pseudomonas aeruginosa has become an important cause of infection, especially in patients with compromised host defense mechanisms. Thus, it is a frequent cause of nosocomial infections. Development of drug resistance in Pseudomonas is worldwide problem and tough challenge to medical practitioners;
Methods: Present study involves the isolation of Pseudomonas from the patients suffering from the ailments like respiratory tract infection, UTI, etc. and studying the antibiotic resistant pattern of these isolates and synergistic action of cold and hot water and methanol extracts of Cinnamomum zeylanicum on the activity of antibiotics by agar diffusion method;
Results: Out of 28 isolates of Pseudomonas isolates five isolates exhibiting wide resistance pattern were selected for study. The results showed synergistic effect of Cinnamomum zeylanicum on the antibiotics which are ineffective against the Pseudomonas isolates. Cold methanol and cold water extract showed good synergistic effect with antibiotics AK, CTX, CAZ, PI, G, CPZ, CPM, CB, NET, TCC, CTR, IPM, AT & AZ against Isolate P-19 making it susceptible to these antibiotics. Hot extract of both methanol and water showed no synergistic effect against Isolate P-19. All the extracts of Cinnamomum zeylanicum have shown no significant synergistic effect on the antibiotics against Isolate P-3, P-4, P-20 and P-26;
Conclusions: Cinnamom extract is effective in combination with antibiotic in dealing the drug resistance problem of Pseudomonas and such synergy is important in exploring the new options for drug resistance problem of many pathogens.

Keywords: Synergy, Cinnamomum zeylanicum, Pseudomonas aeruginosa