Indian Journal of Microbiology Research


MUTATION STUDIES ON STREPTOMYCES FOR AMPHOTERICIN B YIELD IMPROVEMENT


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Author Details: Anitha Upadhyaya, Nagasatya A, Thajuddin N, Paneerselvam A, Upadhyaya Giridhara

Volume : 1

Issue : 1

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 56

Article End Page : 59


Abstract

Four Streptomyces strains isolated from the soil of Western Ghats of India producing Amphotericin B were subjected to random mutagenesis by UV irradiations for yield improvement. The mutants were then screened for their Amphotericin B concentrations and their antifungal activity by agar well diffusion method. Two mutants demonstrated 13% and 16% higher concentration than the isolated strains respectively. Thus mutation can be a very useful tool to minimize production cost with the same benefits.

Keywords: Amphotericin B, UV mutation, Streptomyces, strain improvement