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Indian Journal of Microbiology Research


Emergence of Colistin Resistant Gram Negative Bacilli, in a Tertiary Care Rural Hospital from Western India


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Author Details: Satyajeet Krishnarao Pawar, Geeta Satish Karande, Ravindra Vasantrao Shinde, Vaishali Satyajeet Pawa

Volume : 3

Issue : 3

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 308

Article End Page : 313


Abstract

Background: Colistin is one of the last resort of antibiotics used specifically in the treatment of multidrug resistant gram negative bacilli. Though an older class of antibiotic with no use in last four decades, resurgence of colistin use is also causing emergence of colistin resistant gram negative bacilli.
Objective: The aim of study was to find prevalence of colistin resistance and antibiotic susceptibility pattern of these colistin resistant strains isolated from different clinical specimens in a tertiary care hospital.
Methods: The study included clinical specimens received from wards and Intensive Care Units (ICUs), during January 2015 to December 2015. The specimens were processed by standard method, bacteria were identified by VITEK 2 compact (Biomerieux, France) automation system and antimicrobial susceptibility testing was done with the same system to detect MIC for penicillins, β-lactam/ β-lactamase inhibitor, cephalosporins, carbapenems, aminoglycosides, quinolones, folate inhibitors, glycicyclins and polymixins.
Results: Colistin resistance was observed in 9.98% of the clinical isolates. 51.81% of these colistin resistant strains were Pseudomonas spp. Tigecycline (41.50%) showed maximum sensitivity to colistin resistant strains.
Conclusion: Colistin resistance (9.98%) found in the study is quite alarming. A restricted and rational use of the colistin is the need of hour. A combination of colistin and tigecycline may be useful to prevent further rise of pan drug resistant bacteria.

Keywords:
Colistin, MIC, MDR, Antibiotic, Antimicrobial Sensitivity Pattern