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Indian Journal of Microbiology Research


A study on bacterial infections and their antibiotic susceptibility pattern in decompensated liver disease patients in a tertiary care Hospital


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Author Details: Rajeswari Jayakumar

Volume : 4

Issue : 1

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 36

Article End Page : 39


Abstract

Background & Objectives: Decompensated liver disease (DCLD) is defined as irreversible chronic injury of the hepatic parenchyma. Bacterial infections are more common in decompensated liver disease and causes 30%-50% of deaths. Therefore, this study was done to determine the various bacterial agents causing infections in decompensated liver disease patients and to determine the drug susceptibility and resistance pattern.
Methods: A prospective study was conducted over a period of one year in a tertiary care hospital. Ascitic fluid, urine, sputum, blood and wound swab were collected. All the samples were processed through Gram’s stain and culture. The organisms were identified by standard protocols and antibiotic susceptibility testing.
Results &Conclusion: Out of 150 samples, culture positivity seen in 81(54%). In 81 culture positive isolates, 63(78%) were Gram Negative bacilli (GNB) and 18 (22%) were Gram Positive cocci (GPC). Among Gram negative bacilli, Escherichia coli and in Gram positive cocci, Staphylococcus aureus was the most common isolates. The most common infections were spontaneous bacterial peritonitis (27%) followed by urinary tract infections (26%), Spontaneous bacteraemia (19%), pneumonia (16%), and skin and soft-tissue infections (12%).

Keywords:
Decompensated Liver Disease, Spontaneous Bacterial Peritonitis, Escherichia coli, Staphylococcus aureus