Volume : 4
Issue : 1
Online ISSN : 2394-5478
Print ISSN : 2394-546X
Article First Page : 104
Article End Page : 109
Background & Objectives: Streptococcus pyogenes producing quinolone resistance are an increasing cause of concern in the hospitals as they produce a therapeutic dilemma for the treating physician. The present study was undertaken to know the prevalence of quinolone resistant streptococcus pyogenes from clinical isolates and their antibiotic resistance pattern.
Methods: A total of 28 streptococcus pyogenes were recovered from various clinical specimens. All the samples were processed for routine bacterial culture and antimicrobial susceptibility test as per standard protocol (CLSI, Koeneman’s Text Book).
Results: Of 28 streptococcus pyogenes isolates 8(34.78%) were showing Quinolone resistance. In this study, we investigated antimicrobial activity of 20 widely used antibiotics against S. pyogenesisolates. Tetracycline (53.57%), Ampicilin (32.14%), Erythromycin (32.14%) Cotrimoxazole (39.28%), Levofloxacin (28.57%) and Ciprofloxacin (28.57%) were resistant. Cephalosporins like Ceftazidime (21.42%), Cefotaxime (21.42%) and Azithromycin (21.42%) were less resistant. Cefepime (10.71%), Linezolid (7.14%) and Vancomycin (3.57%) were least resistant. All the isolates were sensitive to Meropenem. Majority of Quinolone resistance isolates were resistant to tetracycline.
Conclusion: Of 28 streptococcus pyogenes isolates 8(34.78%) were showing Quinolone resistance. Cefepime (10.71%), Linezolid (7.14%) and Vancomycin (3.57%) were least resistant. All the isolates were sensitive to Meropenem.
Keywords: Streptococcus Pyogenes. Quinolone resistance, GAS Infection, Therapeutic options