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Indian Journal of Microbiology Research


Fosfomycin susceptibility on uropathogens in a tertiary care hospital, Mandya institute of medical sciences, Mandya


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Author Details: Sharlee R*,Sumangala B

Volume : 6

Issue : 1

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 15

Article End Page : 17


Abstract

Introduction: Urinary tract infection (UTI) is an important cause of illness in humans with emergence of multidrug resistance. Fosfomycin remains to be effective against MDR uropathogens. We evaluated susceptibility of Fosfomycin against uropathoges.
Materials and Methods: A prospective study was conducted for a period of 6 months in a tertiary care hospital MIMS, Mandya. Significant bacterial growth were identified in urine samples and processed accordingly. Fosfomycin susceptibility was performed by Kirby-Bauer disc diffusion method along with other drugs advised as per CLSI guidelines.
Results: A total of 893 urine samples were received, 150 samples showed significant growth of one or two organisms, yielding a sum of 162 isolates. Out of 162 isolates with significant growth of organisms, majority were Gram negative bacilli (GNB) accounting for 63.6% (103 isolates) followed by Gram positive cocci (GPC) 36.4% (59 isolates).
Out of 103 GNB, ESBL producer were 25.2%, Carbapenamase producer were 1.9%, Amp C were 6.8%, ESBL+ Carbapenamase were 4.9%, Amp C + Carbapenemase were 2.9% and 58.3% were non ESBL, Carbapenamase and AmpC producer.
Out of 162 isolates, 156(96.3 %) were sensitive to Fosfomycin and 6 (3.7%) were resistant to Fosfomycin.
Conclusions: Fosfomycin is effective against MDR, ESBL, AmpC and Carbapenamse producing uropthaogens. It is an effective, convenient and safe drug for treating the patients of all age group and pregnant mothers with uncomplicated UTIs.

Keywords: UTI, MDR, AmpC, ESBL, GPC, GNB.

Doi :-https://doi.org/10.18231/2394-5478.2019.0004