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Indian Journal of Microbiology Research

Study of the Prevalence of Neonatal Septicaemia with Antibiotic Susceptibility in a Large Tertiary Care Hospital

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Author Details: Sadhna Sodani, Anita Mutha

Volume : 2

Issue : 3

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 177

Article End Page : 185


Introduction: Invasion of the blood stream by microorganisms constitutes one of the most serious situations in infectious disease and as a result, timely detection and identification of blood borne pathogens is one of the most important functions of the microbiology laboratory. Positive blood cultures may help provide clinical diagnosis, as well as a specific etiological diagnosis.

Neonatal septicemia constitutes an important cause of morbidity and mortality amongst neonates in India. However, with presently available antimicrobial agents, neonatal septicemia may be treated successfully. Early diagnosis and proper management of neonatal septicemia can bring down the morbidity and mortality substantially. Hence, the present study was undertaken to study the bacteriological profile of neonatal septicemia cases and their antimicrobial sensitivity pattern for planning strategy in the management of these cases.
Materials and Methods: This retrospective study was carried out in the CNBC and MYH, department of microbiology and paediatrics, M.G.M. medical college and M.Y. hospital, Indore, from January to December in 1000 blood cultures. Identification of organism was done as per standard methods like gram’s staining, cultural characteristics, motility and biochemical reactions.
Results: In our study done on 1000 neonatal blood cultures, we found 42.2 % cultures were positive, in which 51.3 % were males and 48.7 % were female neonates. We found 52.8 % were Early onset septicaemia (EOS) (<2 days) and 47.2 % were late onset septicemia (LOS) (>2 days). Among 1000 neonates 543 were institutional delivered (inborn) and 457 were out born referred from other hospitals;
64.7 % were term, 35.3 % were preterm, 80.1 % were normal deliveries and 19.9 % were LSCS.
Key words: Septicaemia, Blood culture, CoNS, MRSA, EOS, LOS