Indian Journal of Obstetrics and Gynecology Research


Comparison of single loading dose magnesium sulphate regimen with low dose magnesium sulphate regimen in the treatment of eclampsia


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Author Details: Sunitha HB, Sonam Parikh, Manjushree R Waikar, Vinayak Panchgar, Akshaya N. Shetti

Volume : 4

Issue : 4

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 338

Article End Page : 342


Abstract

Introduction: Eclampsia contributes to maternal mortality in developing, underdeveloped world. Various drugs have been tried to treat eclampsia. Magnesium sulphate has become the drug of choice due to various advantages and is associated with adverse outcome for both mother and fetus if not used correctly. This study was undertaken to know safety, efficacy of reduced doses of Magnesium sulphate as compared to standard dose.
Materials and Method: After obtaining institution ethical clearance and written informed consent this study was conducted on 60 subjects for 2 years. Patients diagnosed as eclampsia and presenting with generalized tonic clonic seizure during antenatal, intrapartum, postnatal were included. Group A received single loading dose of magnesium sulphate (4gm (20%) I V over 3-5 min followed by 10gm (50%) deep i.m. (5gm in each buttock)). Group B patients received low dose magnesium sulphate (4gm (20%) i.v. over 3-5 min followed by 6gm (50%) deep i.m. (3 gm in each buttock) and maintenance dose of 3 gm i.m., every 4 hourly in alternate buttock) which was continued 24 hours after last convulsion or delivery whichever is later. Mode of delivery, recurrence of convulsion, maternal and fetal morbidity and mortality were studied.
Results: Maternal and foetal outcome was comparable in both the groups. There was no significant difference with regards to recurrence of convulsions. There was no statistically significant increase in incidence of caesarian section in group B compared to group A (p>0.05).
Conclusion: Single dose regime controls the eclamptic convulsions with good maternal and neonatal outcome.

Keywords:
Eclampsia, Low dose, Magnesium sulphate