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Indian Journal of Obstetrics and Gynecology Research


Comparative study of oral versus vaginal misoprostol 25 mcg for induction of labour at term in a Medical College Hospital in South India – Prospective Study


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Author Details: P. Thulasi, Balakrishnan R, Shanthi M

Volume : 4

Issue : 4

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 389

Article End Page : 391


Abstract

Objective of the study is to compare the safety and efficacy of oral versus vaginal misoprostol 25mcg for induction of labour at term and to assess perinatal out come.
Materials and Method: Study was conducted in the department of Obstetrics and Gynecology (OBG) at P K Das Institute of Medical Sciences, Vaniamkulam. It was a one year study. It is a comparative prospective study on 300 patients admitted at term for safe confinement. The patients were divided into 2 groups – 150 in each – 25 mcg oral misoprostol / 25mcg vaginal.
Results: There is no statistically significant association between parity and route of administration of drug. There is statistically significant association between Premature Rupture of Membranes (PROM) and route of administration of drug.
In oral group- 66.6 % had Induction Delivery interval between 8-12 hrs and in vaginal group – 68% had Induction Delivery interval between 8-12hrs.
In oral group - 100 % had 2 repeat doses. In vaginal group - 90% had 2 repeat doses.
In oral group, 80% had normal delivery. Only 6.66% had LSCS.
In vaginal group, 73.33% had normal delivery. 13.33% had LSCS.
In oral group, 96.66% had no NICU admission. In vaginal group, 97.33% had no NICU admission.
Among the oral group of those patients who had atonic Post Partum Hemorrhage (PPH), three required blood transfusions.
Conclusion: In our study, oral misoprostol 25mcg is as effective as vaginal misoprostol 25mcg for induction of labour at term with minimal maternal and fetal complications.

Keywords: Induction of labour, Misoprostol, Maternal complication, Fetal complication.

 

Doi No:-10.18231