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International Journal of Oral Health Dentistry


Management of Oral Leukoplakia with Photodynamic Therapy


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Author Details: Sujata K. Satoskar, Aarathi S Shenoy, Sapna Raut Dessai

Volume : 2

Issue : 2

Online ISSN : 2395-499X

Print ISSN : 2395-4914

Article First Page : 99

Article End Page : 101


Abstract

Premalignant lesions like Oral Lichen Planus (OLP), Oral Leukoplakia (OL) has a fair probability of transforming into malignancy and they are perverse toward conventional therapies. Photodynamic therapy (PDT) has been considered as an alternative/ complimentary therapeutic modality for the management of premalignant lesions. Photodynamic therapy (PDT) is a noninvasive method for the treatment of premalignant lesions and head and neck. The principle of PDT is a nonthermal photochemical reaction, which requires the simultaneous presence of a photosensitising drug (photosensitiser), oxygen, and visible light. After a period to allow the photosensitiser to collect in the target tissue, the photosensitiser is activated by exposure to low-power visible light of a drug-specific wavelength. PDT is a cold photochemical reaction, and the photosensitising agents are of inherently low systemic toxicity. This article describes the role of non-surgical management of Oral Leukoplakia with use of Photodynamic Therapy.

Keywords:
Oral Leukoplakia, PDT, ALA, Monochromatic red light, Mucosa