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International Journal of Oral Health Dentistry


“STAMPS” SMART THERAPY AGAINST STREPTOCOCCUS MUTANS: REVIEW ARTICLE


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Author Details: Jeevitha Murugesh, A.S.R.S. Sameera, Shabina Aysha

Volume : 1

Issue : 2

Online ISSN : 2395-499X

Print ISSN : 2395-4914

Article First Page : 81

Article End Page : 84


Abstract

Streptococcus mutans has been implicated as the major acid producing cariogenic bacteria. Dietary sugars and other factors may cause an imbalance of oral micro flora that permits S. mutans to become dominant in the multi-species bio films on the tooth surface, which could lead to dental caries. The application of broad-spectrum antimicrobials often results in re-colonization, ecological disruption and re-dominance of S. mutans within oral flora resulting in secondary infections or other negative clinical consequences. To address this problem researchers have recently developed a new class of pathogen – selective molecules, called specifically (or selectively) targeted antimicrobial peptides (STAMPs), based on the fusion of a species - specific targeting peptide domain with a wide spectrum antimicrobial peptide domain.


Keywords: Specifically targeted antimicrobial peptides, Streptococcus mutans.