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IP International Journal of Ocular Oncology and Oculoplasty


Chemotherapy for Retinoblastoma


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Author Details: Rajarathna Thangavel, Hakan Demirci

Volume : 2

Issue : 4

Online ISSN : 2581-5016

Print ISSN : 2581-5024

Article First Page : 222

Article End Page : 226


Abstract

Retinoblastoma is the most common primary malignant intraocular tumor of childhood. It has a mortality close to 60% in the developing world. With early diagnosis and treatment, survival rates could be high as 95%. Management of Retinoblastoma has undergone a paradigm change in the past two decades with globe salvage becoming the goal of treatment. Safety and efficacy of chemotherapeutic agents combined with their targeted delivery has increased the success rates of tumor control. This article reviews the treatment strategies using different routes of drug delivery to contain ocular and extraocular retinoblastoma, the risks and benefits and future of chemotherapy.

Keywords: Retinoblastoma, Chemotherapy, Intra-arterial melphalan, IAC, Intravitreal melphalan, Periocular cisplatin, VEC regimen