Autologous bone marrow cells for avascular necrosis femoral head
Avascular necrosis (AVN) of the femoral head can be a devastating progressive disease most commonly affecting patients younger than 40 years of age. Although the exact pathophysiology of AVN has yet to be elucidated, the disease is characterized by a vascular insult to the blood supply of the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes. If AVN is diagnosed in the early stages of the disease, it may be possible to attempt surgical procedures which preserve the hip joint, including decompression of the femoral head augmented with concentrated bone marrow. The use of autologous stem cells has shown promise in halting the progression of AVN of the femoral head, and subsequently preventing young patients from undergoing total hip arthroplasty. We studied five patients of stage 2 osteonecrosis of femoral head with core decompression and insertion of autologous mononuclear cells with aseptic precautions. There was significant reduction in pain and joint symptoms with no further radiological progression in 12 months of follow up.
Keywords: Avascular necrosis, Concentrated bone marrow, Femoral head, Osteonecrosis, Stem cells