IP International Journal of Orthopaedic Rheumatology

Innovation of a Novel Therapeutic Modality for Treatment of Osteoarthritis of Knee with Autologous Adipose Derived Stromal Vascular Fraction (AD-SVF)

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Author Details: Prashant Kshatriya, Anant Marathe, Jaymesh Thadani, Shivani Vakodikar, Rajni Vyas, Ramesh Bhonde

Volume : 3

Issue : 2

Online ISSN : 2581-9151

Print ISSN : 2581-8112

Article First Page : 59

Article End Page : 66


Background: Adipose tissue derived stromal vascular fraction is crude heterogeneous mixture of different cell population. SVF possess potential to translate into oesteogenic and chondrogenic lineage. We designed a pilot study to assess safety and efficacy of autologous adipose derived stromal vascular fraction (AD-SVF) in 25 patients (50 knees) with both the knees having osteoarthritis.
Methods: Patients were selected based on selection criteria. Lipoaspiration from the lower abdomen was done. The lipoaspirate was processed to obtain SVF. The intra-articular injection of SVF and PRP was given. Clinical outcomes were assessed with WOMAC, KSS, and VAS scores and radiologically at the interval of 6 weeks, 6 months and 1 year.
Results: The safety of AD-SVF was confirmed as there were no adverse reactions related to therapy. Patients exhibited rapid and progressive improvement of WOMAC, KSS and VAS Score by 1 year. MRI studies did not show radiological evidence of cartilage.
Conclusions: AD-SVF therapy is safe & efficacious alternative treatment for knee osteoarthritis. The intervention is simple, minimally invasive, require minimal hospitalization and surgery.

Keywords: Osteoarthritis, Adipose derived Stromal Vascular Fraction, Stem cell, alternate therapeutic intervention