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Indian Journal of Orthopaedics Surgery


Clinical outcome of Giant cell tumor of bone in South Indian Population


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Author Details: Subbiah Shanmugam, Gopu Govindasamy, Sujay Susikar, Jagadeesan G. Mani

Volume : 3

Issue : 2

Online ISSN : 2395-1362

Print ISSN : 2395-1354

Article First Page : 202

Article End Page : 208


Abstract

Introduction: Inadequate knowledge still exists about Giant Cell Tumor of Bone (GCTB) incidence, treatment and prognosis and moreover, standard treatment has not been formulated till date. Hence, the objective of the present study is to assess the demographic characteristics, treatment modalities and its complications, post-operative functional outcome assessment and long-term prognosis of south Indian population with GCTB, treated from tertiary cancer center in Chennai.
Materials and Method: A retrospective study of prospectively maintained data was conducted in 33 GCTB patients treated at Government Royapettah Oncology Centre (Chennai) from January 2009 to December 2016. SPSS software of version 21.0 for windows was employed for statistical analysis.
Results: The mean age of the studied populations was 31.06 ± 10.83 years (range from 15 – 65 years, median-27 years). The mean duration of follow-up period was 9.6 + 6 months (range from 2 to 24 months). The male to female ratio was 1:1.5(male: 13(39.4%) and Female (20 (60.6%). GCTB patients underwent treatment ranging from cryotherapy, intralesional curettage alone and wide local excision to resection with or without reconstruction with custom mega prosthesis for different anatomical locations.
Conclusion: From our analysis, we conclude that the GCTB patients of south India possess slightly different characteristics in terms of higher incidence in radial bone. In conclusion, resection with CMP reconstruction may be a suitable surgical option for advanced stage GCTB patients with reduced complication rate and provide good functional limb. Hence, devising an early identification and treatment strategy according to risk stratification becomes mandatory.

Keywords:
Giant cell Tumor, Benign aggressive Bone tumor, CMP reconstruction