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International Journal of Pharmaceutical Chemistry and Analysis


Pharmacokinetic evaluation of ritonavir crystallo co-agglomerates in rat module


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Author Details: Santosh V. Gandhi, Rasika R. Korhale, Swati U. Kolhe

Volume : 3

Issue : 2

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 80

Article End Page : 83


Abstract

The present work was done to evaluate pharmacokinetic parameters of ritonavir standard, ritonavir crystallo co agglomerates and marketed formulation of ritonavir. The aim of formulation of Ritonavir crystallo co agglomerates was immediate drug release and solubility enhancement. The analysis was carried out by HPLC. The parameters evaluated were Cmax, Tmax, area under curve (AUC 0-t, AUC 0-∞), t1/2, k elimination (ke).

Key Words
: Ritonavir, Pharmacokinetic study, HPLC, Crystallo co agglomerates