International Journal of Pharmaceutical Chemistry and Analysis

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Synthesis, characterization and evaluation of some benzothiazole derivatives bearing oxindole moiety as potential anticancer agents

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Author Details: Kakadiya Dipesh, Malleshappa N. Noolvi

Volume : 3

Issue : 3

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 143

Article End Page : 149

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Abstract

This study was aimed at investigating the antitumor activity of novel 5-substituted 2-oxindole derivatives. A series of oxindole derivatives of N-(1,3,4-thiadiazol-2-yl)benzo[d]thiazol-2-amine were prepared and confirmed by 1H NMR, mass and IR data. These compounds were evaluated for their anticancer activity at National Cancer Institute (NCI), USA by single High dose (10^-5 M) in full NCI 60 cell panel. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel representing leukaemia, melanoma and cancers of lung, colon, brain, breast, ovary, kidney and prostate. Among them compound 1[D] has showed moderate anticancer activity while compound 3[A-2] has showed significant anticancer activity with overall mean growth percent 38.25. These findings prompt us to further explore the oxindole structure as leading scaffold to design new molecules with potent antitumor activity.

Keywords: 2-Oxindole, 1,3,4-thiadiazole, Benzothiazole, Anticancer, NCI