International Journal of Pharmaceutical Chemistry and Analysis

Antimicrobial Activity of Synthesised Novel N10-Alkyl Substituted Acridine-9-one Derivatives

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Author Details: S. K. Gupta, Pankaj Baboo

Volume : 1

Issue : 1

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 39

Article End Page : 46



N-Phenyl anthranilic acid was prepared by Ullmann condensation of o-chlorobenzoic acid and aniline. The N-phenyl anthranilic acid was cyclized with polyphosphoric acid over a water bath at 100°C to form acridin-9(10H)-one. N10-Alkylated acridin-9-ones were synthesized in two series, in first series, N10-alkylation with 1-bromo-3-chloro propane and in second series with 1, 2-dichloroethane were done by using tetrabutyl ammonium bromide as phase transfer catalyst. Later both were derivatized by refluxing with different secondary amines in presence of potassium carbonate using anhydrous acetonitrile as solvent. The newly synthesized compounds were purified by column chromatography. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.