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International Journal of Pharmaceutical Chemistry and Analysis


Formulation and Evaluation of Cefpodoxime Proxetil Buccal Film


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Author Details: Ajitha K Cherian1, *, Sr. Daisy P A2, Noby Thomas3, Praveen Raj4, Liji Jacob5, Boby Johns George6 and

Volume : 2

Issue : 1

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 1

Article End Page : 13


Abstract

                 Drug delivery through the buccal mucosa offers a novel route of drug administration. Buccal films are highly flexible and readily tolerated by patients than tablets. Thus it was planned to formulate buccal films of Cefpodoxime proxetil using Chitosan, Gelatin and Pectin as main polymeric substrates. It can be used in the treatment of respiratory, urinary, skin and soft tissue infection caused by gram positive and gram negative bacteria. Various pre-formulation studies such as Infrared spectroscopy and solubility were conducted and seven formulations were prepared by solvent casting method. Physical evaluations such as physical appearance and surface texture, weight variation, mean thickness, swelling index, folding endurance, surface pH, moisture loss & moisture absorption studies and mechanical evaluations such as tensile strength, elongation at break were carried out. From the in vitro dissolution studies F6 was found to get a maximum cumulative drug release of 98.91% upto 390 minutes and selected as the optimized film containing polymers chitosan, HydroxyPropyl Methyl Cellulose, Polyvinyl Pyrrolidone and Propylene Glycol as plasticizer. Further evaluations such as anti-microbial study, stability study and release kinetics was calculated for the optimized film and is found to be within the limit.

 

Keywords: Cefpodoxime proxetil, Chitosan, solvent casting method, swelling index, in vitro drug release, anti-microbial study, stability study.