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International Journal of Pharmaceutical Chemistry and Analysis


Biological evaluation of 2-Arylidene-4-(substituted aryl) but-3-en-4-olides


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Author Details: Asif Husain, Aftab Ahmad, Shah Alam Khan, Mymoona Akhter

Volume : 2

Issue : 3

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 120

Article End Page : 122


Abstract

The aim of this study was to evaluate the in vitro anthelmintic activity of 2-Arylidene-4-(substituted aryl) but-3-en-4-olides (I-IX) against Indian earthworm i.e. Pheretima posthuma. The anthelmintic activity of nine butenolide derivatives was determined by recording the mean paralyzing and death times of the worms at concentration of 2 mg/mL. The results indicated that few of the tested butenolide derivatives possess significant anthelmintic activity comparable to positive control, albendazole.

Keywords:
  Furanone, Pheretima posthuma, Anthelmintic, Albendazole