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International Journal of Pharmaceutical Chemistry and Analysis


Free Radical Scavenging and Anti-inflammatory Potential of Methanolic Extract of Flowers and Roots of Cassia auriculata Linn


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Author Details: Manoj V. Girase, Monika L. Jadhav

Volume : 2

Issue : 3

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 123

Article End Page : 129


Abstract

Background & objectives: The objective of present study is to find free radical scavenging and anti-inflammatory activity of methanolic flowers and roots extracts of Cassia auriculata Linn.
Methods: The methanolic flowers and roots extracts of Cassia auriculata Linn. were investigated for their antioxidant potential and anti-inflammatory activity  by using  carrageenan-induced acute inflammation and cotton pellet-induced sub-chronic inflammation in rats.
Result: The methanolic flowers extract of Cassia auriculata exhibited significant antioxidant and anti-inflammatory activity by reducing carrageenan and cotton pellet induced change in bio-chemical parameters. The methanolic flowers extract showed 54.20 % and 55.76% while methanolic roots extract showed 52.52% and 53.84% inhibition in carrageenan-induced, cotton pellet-induced inflammation in rats respectively. Both the extracts of flowers and roots were tested for the presence of phytochemical constituents and studies confirmed the presence of the active phytoconstituents in methanolic extract of flowers, which may interfere with free-radical formation and accounts for the significant anti-inflammatory activity.
Interpretation & conclusions: The present study indicates the medicinal value of Cassia auriculata in the management of inflammation.

Keywords:
Cassia auriculata, Antioxidant, anti-inflammatory, Carageenan, cotton pellet.