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IP International Journal of Periodontology and Implantology


An autologous indigenous armour -- Platelet Rich Plasma


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Author Details: MV Ramoji Rao, D. Rachita Rao, P. Lakshmi Preethi, M. Sathish, PV Prasanna Kumar

Volume : 2

Issue : 3

Online ISSN : 2457-0087

Print ISSN : 2581-9836

Article First Page : 75

Article End Page : 82


Abstract

A major goal of periodontal therapy is regeneration of the attachment structures such as alveolar bone, periodontal ligament and cementum. Open flap debridement results in the formation of long junctional epithelium, which is more susceptible to microbial invasion and is thought to be a less stable attachment. However regeneration is thought to partially mimic developmental mechanisms, which require a coordinated orchestration of cellular events such as proliferation, migration and differentiation. Polypeptide growth factors are naturally occurring biological modifiers that have the potential to alter the host tissue to stimulate or regulate the wound healing process. They can regulate key cellular events in tissue regeneration, including cell proliferation, chemotaxsis, differentiation, and matrix synthesis via binding to specific cell surface receptors. Platelet rich plasma is exactly what its name suggests. The substance is a by-product of blood (plasma) that is rich in platelets. It contains platelets, coagulation factors and plasma proteins. PRP permits the body to take advantage of the normal healing pathways at a greatly accelerated rate, which play an important role in regeneration of periodontal tissue. Scientific proof of bone and soft tissue healing has been shown using platelet concentrate with viable platelet levels increased 300% to 600% above baseline levels. The more growth factors that can be delivered to the injury site, the greater the potential to enhance the healing process.

Keywords: Platelets, Periodontal regeneration, Wound healing, Platelet rich plasma, Growth factors