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Indian Journal of Pathology and Oncology


A study of Transferrin expression in comparison with Modified Scarff- Bloom Richardson’s grading system in Breast carcinoma


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Author Details: Rajeswari Kathiah, Meenakshisundaram K, Anushuya G, Rajalakshmi V

Volume : 3

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 38

Article End Page : 41


Abstract

Background & Objectives: Breast carcinoma is the most common malignancy in women worldwide and extensive researches have been made with development of many prognostic, predictive and theranostic markers[1]. One of the powerful prognostic predictor in histology is Modified Scarff- Richardson and Bloom grading system[MSBR] also known as Nottingham grading system by which tumours are classified as grade 1, 2 and 3[2,3]. Transferrin is a potential marker for identification of dividing cells detected by routine immunohistochemistry. Its expression correlates with the cellular proliferation, being highest in rapidly dividing cells and much lower in resting and terminally differentiated cells[4]. The aim of the study was to assess the proliferative status of the breast carcinomas with transferrin immunostaining and to compare and analyze the association with MSBR grading system for the assessment of prognosis.
Materials & Methods: A total number of 40 randomly selected patients undergoing mastectomy were investigated. The tumours were categorized as Grade 1, 2 & 3 according to the MSBR grading system. The sections were also immunostained with monoclonal antibodies against transferrin and its intensity of expression was studied. The obtained results were statistically analyzed.
Results & Interpretation: A strong statistically significant correlation was found between MSBR grading and transferrin expression.
Conclusion: Staining pattern of transferrin is more of prognostic significance in breast tumors than diagnostic value and may facilitate the decision making process in the treatment of individual cases of carcinoma breast.

Keywords: Breast cancer, Transferrin, Modified Scarff- Richardson and Bloom grading system, MSBR