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Indian Journal of Pathology and Oncology


Study of thrombocytopenia in neonatal intensive care unit


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Author Details: Sonam S. Nandyal, Shashikala P, Vidhushi Sahgal

Volume : 3

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 55

Article End Page : 59


Abstract

Background and Objectives: Neonatal thrombocytopenia (platelet count less than 150×109/L) is one of the commonest hematological abnormality encountered in neonatal intensive care unit (NICU). Though thrombocytopenia is so prevalent it is often overlooked assuming that it will resolve spontaneously. However, if it is not detected and managed properly can result in devastating complications. The present study highlights the pattern, prevalence, severity and possible causes of neonatal thrombocytopenia encountered in our hospital.
Method: A prospective observational study was conducted on sick neonates admitted to NICU with different clinical problems and were evaluated for pattern and severity of thrombocytopenia as per the blood samples analysed.
Results: Out of 155 consecutive neonates admitted to NICU, 99 developed thrombocytopenia with a high prevalence of 63.8%. 43.4% had early onset and 56.5% had late onset thrombocytopenia. The most common cause of neonatal thrombocytopenia was prematurity (38.3%) followed by neonatal sepsis (22.2%). Mild and moderate thrombocytopenia was found in 17.1% of the neonates each, while severe was more common accounting for 65.6% of cases.
Conclusion: Neonatal thrombocytopenia is common in NICU and it could be used as a prognostic marker for multiple diseases. As its clinical course and outcome depend on etiology, an appropriate diagnostic workup is essential for early diagnosis and better management.

Key words: Neonate, thrombocytopenia, neonatal intensive care unit, pattern of thrombocytopenia