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Indian Journal of Pathology and Oncology


Role of Argyrophilic nucleolar organiser regions [AgNOR’s] in preneoplastic lesions of prostate


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Author Details: Meenakshisundaram K, Rajeswari K, Rajalakshmi V

Volume : 3

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 86

Article End Page : 91


Abstract

Aims and objectives: 1. To demonstrate the patterns in different premalignant lesions of prostate. 2. Correlating AgNOR counts with various grades of PIN.
Materials and methods: This study was conducted in 83 cases of different prostatic biopsy specimens from 2013 -2015. All biopsy samples were routinely processed and stained with both haematoxylin and eosin and with AgNOR stain.
Results: The mean AgNOR count and score of high grade prostatic intraepithelial neoplasia was significantly high when compared to low grade intraepithelial lesion. High grade prostatic intraepithelial lesions associated with nodular hyperplasia or with carcinoma was the same.
Conclusion: AgNOR is a simple, cost effective and easy stain to evaluate the proliferative activity of the cell. It can be used as an additional test which will be of immense value regarding the progression of preneoplastic lesions in prostate.

Keywords: AgNOR, low grade PIN, high grade PIN.