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Indian Journal of Pathology and Oncology


Undifferentiated carcinoma of the gall bladder: a rare entity


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Author Details: Medhi Pranita, Dowerah Swagata, Dutta Utpal, Dutta Aparna

Volume : 3

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 124

Article End Page : 128


Abstract

Undifferentiated carcinoma of the gall bladder is an unusual tumor with a reported incidence of 0.38% of all gallbladder and extrahepatic bile duct cancers. We present a 65 year old female presenting with pain abdomen who was diagnosed with carcinoma gall bladder on ultrasound and CT abdomen. Histopathological examination revealed a 6.5x4x2 cm3 growth extending from the body of the gall bladder upto the fundus. H & E stained sections from the growth revealed sheets and trabeculae of neoplastic cells which were round to polygonal with abundant eosinophilic cytoplasm, multinucleation at places and areas showing spindled tumor cells. A diagnosis of undifferentiated carcinoma of gall bladder with spindle and giant cell type was given. Tumor showed strong positivity for cytokeratin and vimentin. These tumors have a very poor prognosis and therefore early diagnosis is vital to the survival of the patient.

Keywords: Undifferentiated carcinoma, Gall bladder, Spindle and giant cell type