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Indian Journal of Pathology and Oncology


Clinical and Histopathological Spectrum of Vesciculobullous Lesions of skin- A Study of 40 cases


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Author Details: Anirudha Vasantacharya Kushtagi, Vijayashree Shivappa Neeravari, Sidhalingreddy, Pratima S

Volume : 3

Issue : 2

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 152

Article End Page : 158


Abstract

Background: Vesiculobullous lesions of skin areheterogenous group of dermatological disorders and are not uncommon. These lesions may present with common clinical presentation as blister clinically, but histopathological features differ.
Aims & Objective: This study is under taken to study the clinical and histopathological features of vesciculobullous disorders.
Materials and Methods: A total 40 cases of clinically diagnosed blistering disorder were included, the punch biopsy of the lesion was taken. The biopsy was studied for histopathologicalfetures like level of blister formation, acantholysis, spongiosis, basement membrane zone distruction, presence or absence of inflammation.
Results: In the present study amongst 40 cases, Pemphigus vulgaris was diagnosed in 12 (30%) cases and detected as most common type, followed by Bullous Pemphigoid in 11 (27.5%) cases. Herpes gestationis (Bullous Pemphigoid) was diagnosed in only one case. Commonly the blisters were seen on trunk, extremeties, axilla and groin. The lesions were slightly male preponderance in the present study. Most of the cases found between 41-70 years of age.
Conclusion: The distribution of vesiculobullous lesions in relation to gender, age group, presenting site and histopathological features differ in each type. Histopathological examination gives valuable clue in the diagnosis of particular type of blistering disorder.

Key words:
Vesciculobullous, Blister, Histopathological, Clinical, Disorder