Indian Journal of Pathology and Oncology


PATHOPHYSIOLOGY OF FIBROIDS


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Author Details: Harpreet Kaur, Aayushi Gulati

Volume : 1

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 14

Article End Page : 17


Abstract

Fibroids are the commonest benign tumors of female genital tract. They are mainly composed of smooth muscle & fibrous connective tissue. Etiopathogenesis of fibroids is linked to hormones (estrogen & progesterone), genetic factors and some growth factors. Estrogen is the main predisposing factor-there is increased density of estrogen in fibroids compared to normal myometrium and increased concentration of aromatase leading to high local estrogen levels. The growth promoting effect of estrogen & progesterone has been shown to be mediated through local production of growth factors.

 
Key-words: fibroids, pathophysiology, growth factors.