Indian Journal of Pathology and Oncology


STUDY OF COAGULATION PROFILE IN PREGNANCY INDUCED HYPERTENSION (PIH)


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Author Details: Nirmala T, Kumar Pradeep L., Vani B R., Murthy Srinivasa V., Geetha R L

Volume : 2

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 1

Article End Page : 6


Abstract

Background: Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Hypertension is a sign of an underlying pathology which may be pre-existing or appear for the first time during pregnancy. Various haematological changes like numerical and functional platelet abnormalities, alteration in haemoglobin and erythrocyte parameters and hypercoagulable state may be seen.

Aims and Objectives: Evaluation of coagulation profile in PIH.
Materials and Methods: A 2 year study was carried out in the Dept. of pathology ESIMCPGIMSR, Bangalore on 100 PIH cases. Coagulation profile (PT, aPTT, INR and D-dimer) was done in all cases and values were correlated with the severity of PIH.
Results: Total of 100 cases were included in the study. 37 were mild GH, 9 cases were severe GH, 29 cases were mild preeclampsia and 25 cases were in severe preeclampsia group. Prolonged PT, aPTT and D-Dimer was seen in 15 cases, 42 cases and 38 cases respectively. In our study we observed increased mean aPTT of 27.33±4.54 and increased D-Dimer of 0.35±0.33 in severe preeclampsia patients. Hence we emphasize that raised aPTT, D-Dimer are alarming signs for aggressive treatment. Conclusion: Raised aPTT and D-dimer are fairly good indicator of severe preeclampsia and needs aggressive treatment.
 
Key Words: Hypertension, preeclampsia, eclampsia, HELLP Syndrome, D-Dimer.