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Indian Journal of Pathology and Oncology


Study of clinicomorphologic spectrum of prostatic lesions and correlation with prostate specific antigen levels in a tertiary care center


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Author Details: Sanjaykumar C. Chauhan, Ankur N. Sarvaiya

Volume : 4

Issue : 2

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 328

Article End Page : 332


Abstract

Introduction: Benign and malignant lesions of prostate are some of the commonest problem of elderly men age group. Prostate specific antigen level, histopathological examination, and digital rectal examination are considered three most important evaluation criteria.
Objective: To study clinical and histopathologic spectrum of prostatic lesions and compare prostate specific antigen levels in various non-neoplastic, benign and malignant lesions of prostate.
Materials and Method: Study was performed prospectively and retrospectively from January 2013 to December 2016 in the department of Pathology in the tertiary care centre in North Gujarat area over the span of 3 years. Histopathologically Gleason system scoring was analyzed. Prostate specific antigen value was noted in each case.
Results: Mean age of all 140 cases was 65.5± 10.7years, of all BPH cases it was 66.07 years, and 72 years of adenocarcinoma cases. Frequency of urination was most common presenting symptom (42 cases - 30%) followed by difficulty in voiding (38 cases – 27.14%). The commonest histopathological diagnosis was benign prostatic hyperplasia - 90 cases (64.28%), next is adenocarcinoma -38 cases (27.14%). The commonest Gleason system score in prostatic adenocarcinoma cases was score 7. Benign prostatic hyperplasia and Prostate carcinoma cases had mean prostate specific antigen value of 5.05 ± 3.15 ng per ml and 59.65 ±38.65 ng per ml respectively.
Conclusion: Prostate specific antigen value should be measured periodically in elderly men as a screening tool. Each higher value must be followed by histopathological evaluation of prostate biopsy for exact nature of disease confirmation.

Keywords:
Prostate specific antigen, Benign prostatic hyperplasia (BPH), Prostate adenocarcinoma, Gleason score