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Indian Journal of Pathology and Oncology


A rare case of Anaplastic Large Cell Lymphoma


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Author Details: Nidhi Mahajan, Isha Gupta, Anshul Sharma, Kanav Gupta

Volume : 4

Issue : 3

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 473

Article End Page : 475


Abstract

Anaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and a secondary form. We are presenting a case of 54 year old male with multiple nodular lesions and a small non healing ulcer on it over left thigh along with inguinal lymphadenopathy since 3 months. Clinically the patient was diagnosed as Squamous Cell Carcinoma. FNAC from the lymphnode was done and cytodiagnosis of poorly differentiated malignancy was given. However due to presence of few atypical cell, FNAC was done from skin nodule and diagnosis was given as poorly differented malignancy suspicious of anaplastic large cell lymphoma. Confirmation was done by skin biopsy and immunochemistry, tumor cells were positive for CD30,CD 3(focal) and Granzyme B.

Keywords:
ALK, CD30, Embyro shaped nucleus, Granzyme B, Immunohistochemistry