Volume : 4
Issue : 4
Online ISSN : 2394-6792
Print ISSN : 2394-6784
Article First Page : 533
Article End Page : 535
Introduction: Stroke is one of the leading causes of death and disability in India. Various risk factors like smoking, diabetes mellitus, hypertension, hyperlipidemia, obesity and stress are associated with atherosclerosis. Platelets are known to play a critical role in conversion of a chronic atherosclerotic plaque into an occluding thrombus. Various studies have postulated that large platelets or raised mean platelet volume (MPV) are more vulnerable for development of occluding thrombus. The present hospital-based case control study was undertaken to evaluate the importance of platelet volume indices specifically increased MPV in patients with stroke and to compare those values with the normal healthy controls.
Materials and Method: We studied 157 cases of stroke patients admitted in our hospital over a period of two years. Platelet variables of stroke patients were measured in an automated analyzer immediately after hospital admission and preferably within 2 hours. Group matching was done for the control subjects and the controls were matched for age, sex and other demographic characteristics.
Results: There was no significant difference in mean platelet volume between patients with stroke and the control subjects (p value >0.05, Student‘s t test).
Conclusion: Raised MPV or large platelets are not a risk factor for stroke.
Keywords: Large platelets, Mean platelet volume, Stroke