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Indian Journal of Pathology and Oncology


Clinical Significance of CD34 & CD10 Expression in Pediatric Acute Lymphoblastic Leukemia


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Author Details: Amritha Malini G, Rajeevan K, Ajith Kumar VT, Sathi PP, Aravindan KP

Volume : 4

Issue : 4

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 564

Article End Page : 569


Abstract

Introduction: Prognostication of acute leukemia by detecting immunophenotypic marker expression on leukemic cells by flow cytometry is crucial in providing individualized treatment and improving outcome in Pediatric ALL (Acute lymphoblastic leukemia). The Aim of the study was to determine whether expression of CD34 and CD10 could be used as additional prognostic markers in predicting treatment response in Pediatric ALL cases.
Materials and Method: This study was conducted among 44 pediatric ALL cases diagnosed in 2 year period in a tertiary care centre in North Kerala. Peripheral smear (PS), & bone marrow (BM) were examined, clinical and laboratory parameters were studied and flow cytometry was done in all cases and expression of CD10 & CD34 were noted. Treatment response was assessed by examining peripheral smear on day 7 after treatment, BM after induction, Cerebrospinal fluid (CSF) examination during induction phase .All the cases were followed up.
Result: In our study it was observed that presence of blasts on day 7 peripheral smear and CSF were more in CD34 negative cases compared to CD34 positive cases. BM remission after induction, treatment response and good outcome on follow up were more among CD34 positive cases. The results were statistically significant for CD34 expression. CD10 expression alone was not found to be statistically associated with treatment response.
Conclusion: CD34 expression predicts treatment response and is a significant favourable prognostic factor in pediatric ALL cases. It can be included in risk stratification for planning treatment along with established parameters.

Keywords:
Pediatric ALL, CD34, CD10 flow cytometry, Treatment response