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Indian Journal of Pathology and Oncology


A diversity of central nervous system tumours at a tertiary care centre-a one year prospective study


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Author Details: G. Vahini, K. Shilpa Madhuri, BA Ramakrishna, Sumakaza, K. Rammurthy

Volume : 4

Issue : 4

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 580

Article End Page : 585


Abstract

Introduction: Central nervous system tumours represent unique heterogenous population of neoplasms which include both Benign and Malignant neoplasms. In India, CNS tumours constitute about 1.9% of all the tumours. These tumours pose diagnostic difficulty due to varied presentation and overlapping morphological features. Immunohistochemistry helps in overcoming diagnostic difficulties in problematic cases.
Aims and Objectives: The aim of the study is to analyse histopathological spectrum of CNS tumours irrespective of age in a single institution.
Materials and Method: A one year prospective study was carried out in department of pathology from 2016 to 2017, at the department of pathology, ASRAM. Neurosurgical specimens were formalin-fixed and paraffin-embedded and stained with Haematoxylin and eosin. Immunohistochemical markers were applied in selective cases like S-100, CD-45, etc.
Results: In our study, seventy two (72) brain neoplasms were analysed. Neuroepithelial tumours (25) were most common, followed by meningothelial tumours (22), tumours of sellar origin(12), tumours of cranial and paraspinal nerves(5), metastatic tumours(4) and others (4).
Conclusions: The present study highlights the histological diversity of CNS tumours in various age groups. CNS tumours peak incidence was noted at 4th to 5th decade. Meningiomas and astrocytomas were common tumours after 40 years of age. GBM was the most common among astrocytomas. Immunohistochemistry was helpful in dilemmatic cases.

Keywords:
Central, Nervous, System, Tumours

Doi No:-10.18231