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Indian Journal of Pathology and Oncology


Clinicopathological study of neoplastic and non-neoplastic lesions of prostate- two years study


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Author Details: SD Birare, SK Mahule, KT Dalve, NR Patil, NV Naigaonkar

Volume : 4

Issue : 4

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 622

Article End Page : 628


Abstract

Introduction: Among the cancer related deaths in men, prostatic cancer is the second most common to lung cancer. Important cause for prostatic morbidity and mortality includes inflammation, benign nodular enlargement and tumors. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer. The current study aims at analyzing clinicopathological features of various neoplastic and non-neoplastic lesions of the prostate.
Materials and Method: The present study included 158 prostatic specimens, which comprises of 157 TURP chips, and 1 prostatectomy specimen. The results were grouped into non-neoplastic and neoplastic lesions. The cases of prostatic adenocarcinoma were graded using Gleason microscopic grading.
Results: Out of 158 prostatic specimens studied; 145 were benign lesions, 4 were premalignant and 9 were malignant lesions. Among benign lesions nodular hyperplasia without prostatitis was the most common. The cancer detection rate with prostatic volume < 40 ml was higher than with >40 ml. Most malignant prostatic lesions showed marked elevation in serum PSA levels (>20 ng/ml). Among the malignant lesions, commonest lesion was prostatic adenocarcinoma.
Discussion: Since low-grade lesions are usually asymptomatic, awareness of serum PSA level estimation, digital rectal examination should be done among elderly males who are prone for malignancy. Male individuals with a positive family history for prostatic carcinoma must undergo relevant screening test.

Keywords:
Prostate, Hyperplasia, Adenocarcinoma, PSA, Gleason score

Doi No:-10.18231