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Indian Journal of Pharmacy and Pharmacology


Central and Peripheral Antinociceptive Activity of Terminalia Belerica Fruit Pulp Aqueous Extract in Swiss Albino Mice


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Author Details: Manohar V.R, Mohandas Rai, Chandrashekar. R, Smitha Sivan, Bharath Kumar D, Aishwarya Aravind

Volume : 3

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 13

Article End Page : 16


Abstract

Background & Objectives: Pain is the most common disturbing symptom a person experiences in life. Many branded drugs are available in the market for relieving pain and moreover are sold over the counter but carries different adverse drug reactions. The objective of this study was to explore the role of Terminalia belerica fruit pulp aqueous extract in Swiss Albino mice.
Methods: Animals were divided randomly into control, standard and test groups consisting of six animals in each. Group I received the vehicle (1% gum acacia, 10 ml/kg) and served as the control, group II received Tramadol 20mg/kg and Diclofenac sodium 10mg/kg respectively which served as a standard for central and peripheral antinociceptive activity while group III, IV and V received the test drug Terminalia belerica fruit pulp aqueous extract (TBFPAE) in the doses of 9, 18 and 36mg/kg respectively. All the drugs were administered orally one hour prior to experiment and were evaluated for central analgesic activity by Eddy’s hot plate method and peripheral analgesic activity by acetic acid induced writhing reflex in Swiss Albino mice.
Results: Our study has shown an increase in reaction time (p<0.05) in all three doses at 30 minutes interval as compared to the control by Eddy’s hot plate method and also reduced the number of writhes (p<0.05) by acetic acid induced writhing reflex in Swiss Albino mice compared to the control.
Interpretation & Conclusions: Our study has shown central and peripheral antinociceptive activity of Terminalia belerica fruit pulp aqueous extract in swiss albino mice.

Keywords:
Aqueous extract, Central antinociception, Fruit pulp, Peripheral antinociception, Terminalia belerica