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Indian Journal of Pharmacy and Pharmacology


Antihyperlipidemic Effect of Microbially Converted Eicosapentaenoic Acid from Rice Bran Oil in Rats


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Author Details: Shilpa A. Deshpande, Nandkishor J. Duragkar

Volume : 3

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 24

Article End Page : 28


Abstract

Objective: Eicosapentaenoic acid (EPA) from fish oil is known to have favourable effects on cardiovascular system by lowering the elevated lipid levels. With the intention of producing an alternative vegetarian source to fish EPA, we have microbially synthesized EPA (mEPA) from α- linolenic acid (ALA) isolated from rice bran oil which was spectroscopically analysed. The objective of the present study was to evaluate the effect of mEPA on lipid profile in experimentally induced hyperlipidemic rats.
Methods: Animals were divided into 12 groups of six animals each; control being treated with vehicle, 6 groups received normal diet while 6 groups received high fat diet. Both treatment groups received standard drug Atorvastatin (10 mg/ kg in saline, p.o.); three different doses of EPA (5, 10 and 50 mg/kg) and fish oil (1 g/ kg) for 28 days and were compared with sham hyperlipidemic rats. The hyperlipidemia was induced by high fat diet and lipid profile was estimated. 
Results: The elevated levels of LDL, VLDL and triglycerides in high fat diet induced animals were found to be decreased in the treatment groups whereas the decreased levels of HDL in hyperlipidemic group were significantly increased in the mEPA treated groups. The atherogenic index was improved with mEPA treatment.
Conclusion: mEPA has shown promising antihyperlipidemic effect and can fulfil the need of alternative vegetarian source of EPA than fish oil to be used in the hypertensive hyperlipidemic conditions.

Key words:
Antihyperlipidemic, Eicosapentaenoic acid, hyperlipidemia, High fat diet, Lipid profile