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Indian Journal of Pharmacy and Pharmacology


Role of vitamin D on blood sugar level in diabetic patients


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Author Details: Sushma Kumari, Mritunjay Kumar Upadhyay, Ashok Kumar Deo

Volume : 3

Issue : 2

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 49

Article End Page : 51


Abstract

Background: Vitamin D3 has been linked to everything as cancer, diabetes mellitus heart disease etc. One important function of vitamin D is on the beta cells of pancreas that secretes insulin. In cases of deficiency of vitamin D there is not only a decreased secretion of insulin but also increased insulin resistance as proved by various studies. Studies have also shown that treatment of vitamin D deficiency delays the development of insulin resistance & so diabetes mellitus.
Methods: Our objective was to examine the association of serum 25-hydroxyvitamin D levels with type 2 diabetes mellitus & effects of vitamin D on it. Analysis were carried out on 200 patients (120 men & 80 women) aged about 35 or above conducted for 1 year in 2014. Diabetes mellitus was defined as fasting plasma glucose > 126mg% or current use of oral hypoglycaemic agents or insulin.
Results: Compared to individuals with a sufficient serum 25(OH)D concentration >75nmol/L, the observed values are divided into 4 groups severe (<25nmol/L), mild (25 to <50 nmol/L), moderate (50 to<75nmol/L) & normal >75nmol/L. The enrolled patients were investigated for blood sugars, vitamin D levels, lipid profiles & HbA1C status at baseline & at the end of 1 year.
Conclusion: Correction of vitamin D deficiency postpones the development of insulin resistance & thus diabetes mellitus & also improves glycemic control.

Keywords
: Vitamin D, Type 2 Diabetes Mellitus, Insulin resistance, HbA1C