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Indian Journal of Pharmacy and Pharmacology

Evaluation of antidepressant effects of rosuvastatin in male albino mice by forced swim test model

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Author Details: Avanthi E, Pradeep Kumar L, Lokesh BN, Yadavalli Guruprasad

Volume : 3

Issue : 2

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 73

Article End Page : 74


Objective: To evaluate the antidepressant activity of Rosuvastatin in male albino mice.
Method: Thirty male swiss albino mice were selected for forced swim test model. There were five groups and each group had six animals. The control group received Normal saline (10ml/kg I.P), the standard Imipramine (10mg/kg I.P), the 3 test group received Rosuvastatin (10mg/kg, 15mg/kg, 20mg/kg I.P) respectively. The test was conducted 30mins after injecting the drugs by forced swim test model.
Duration of immobility was noted. Statistical analysis was performed using Mean +/- SEM. One way ANOVA followed by Tukey’s post hoc test was done P<0.05 was considered statistically significant.
Results: Rosuvastatin produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the control and standard with significant p value of <0.0001.
Conclusion:  The results of the present study indicates the antidepressant like activity of Rosuvastatin in male albino mice.

Key words:
Rosuvastatin, antidepressant, albino mice.