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Indian Journal of Pharmacy and Pharmacology


To compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm


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Author Details: Seema Rani, Sanjeev Kumar, Joyti, Prem Kumar Vaerma, Dharvin Lamba, Rahul Saini

Volume : 3

Issue : 2

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 79

Article End Page : 83


Abstract

Background & Objectives: Eperisone hydrochloride is a new drug came in market with centrally acting muscle relaxant, having additional vasodilator effect and used for treatment of backache associated with muscle stiffness like thiocolchicoside but supposed to be slightly better in efficacy and adverse effect profile. The aim of this study was to compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm.
Methods: 100 eligible subjects were taken and assessment of severity of pain and muscle spasm was done by using Visual Analogue Scale, finger-to-floor distance (FFD), Lasegue’s maneuver and modified Schober’s test.
Results: No statistically significant difference in pain relief and muscle spasm among both the treatment groups but clinically pain relief is slightly better in eperisone group. The adverse drug reactions occurring during study showed a slightly better safety profile in patients on eperisone than on thiocolchicoside.
Conclusion: These findings confirm that eperisone represents a valuable and safer alternative to thiocolchicoside for treatment of low back pain associated with muscle spasm.

Keywords:
Eperisone, Low backache (LBP), Muscle relaxants, Visual Analogue Scale (VAS), Thiocolchicoside