• Indexing List

Indian Journal of Pharmacy and Pharmacology


The study of antiepileptic activity of clove oil by MES model in mice


Full Text PDF Share on Facebook Share on Twitter


Author Details: Avanthi E, Pradeep Kumar L, Lokesh BN, Yadavalli Guruprasad

Volume : 3

Issue : 3

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 103

Article End Page : 107


Abstract

Background: The objective was to evaluate and compare the effect of extract of essential oil of clove with the standard sodium valproate on MES model.
Methods: A total of thirty mice were taken, they were given an electroconvulsive shock. Thirty mice were divided into five groups of six animals each, the control group received distilled water 5ml/kg i.p, standard received Inj. Sodium valproate 200 mg/kg i.p. another group received Sesame oil – 10ml/kg i.p(control), test groups received Clove oil- 0.075 ml/kg i.p., Clove oil-0.1ml/kg i.p respectively. All the injections were given 30 minutes before the test.
Results: Clove oil produced significant antiepileptic effect at all the doses.
Conclusion: Clove oil has shown significant antiepileptic activity in mice.

Keywords:
Epilepsy, Clove oil, Albino mice, MES model