Indian Journal of Pharmacy and Pharmacology


A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDY OF AZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY


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Author Details: Mallikarjun B Katte, Jagadishchandra S Ratnakar, Lopamudra Banerjee

Volume : 2

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 1

Article End Page : 5


Abstract

It was reported that some 3-amino 2-aryl-1-azolyl-2-butanol have antifungal effects. To understand the structural basis for antifungal activity and guide in the design of more potent agents, we performed quantitative structure activity. The Minimum Inhibitory Concentration (MIC) values of 3-amino-2-aryl-1-azolyl-2-butanol on yeast exhibited a strong correlation with the prediction made by the model developed in the present study. The statistical results of the Training Set, Regression coefficient r (0.841648) and r2 (0.708371) values gave reliability to the prediction of inhibitory activity of a series of Azole derivatives.

Key words: Anti-fungal, Azole, Quantitative Structure Activity Relationship.