Indian Journal of Pharmacy and Pharmacology


THYROXINE: A PUTATIVE NEUROPROTECTANT IN CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY IN RATS


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Author Details: Hariprasad M .G, Rema Razdan, Yash T. C

Volume : 2

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 43

Article End Page : 54


Abstract

Objectives: Anti-neoplastic drugs like Cisplatin, Taxols are associated with the development of peripheral neuropathy (PN). Severe neuropathy can occur in 3% to 7% of treated cases with single agents but can increase to 38% with combined regimens. The treatment options for PN currently include anti-depressants, anti-convulsants and opioid analgesics. These agents are modestly effective for symptomatic relief, but they do not affect the underlying pathology nor do they slow progression of the disease. Therefore, effective treatment for chemotherapy induced neuropathy would be a major advantage for cancer patients. It is well established thyroid hormones lays an important role in regulating the development and regeneration of the nervous system & local administration of triiodothyronine (T3) at the level of transected rat sciatic nerve increased the number and diameter of regenerated axons and SCG10 protein levels about two-fold in the different segments of transected nerve during the regeneration period.SCG10 protein is a regulator of microtubule dynamics in growth cones. The main objective of the study was to evaluate the neuroprotective activity of thyroxine in Cisplatin-induced PN in rats.

Methods: PN was induced by Cisplatin - 2mg/kg,i.p. twice weekly for 8 weeks. The degree of protection was determined by measuring electrophysiological properties of sciatic nerve like nerve conduction velocity, motor in-coordination, thermal &cold hyperalgesia, grip strength and histopathological studies.
Results: PN was evidenced in Cisplatin control rats and ameliorated with administration of T4 (0.1 mg/kg, s.c.) for 4weeks by augmenting all the above parameters.
Conclusions: T4 exhibited neuroprotective activity, which would be attributed to its activity as neurotrophic effect.
Keywords: Cisplatin, Neuroprotectant, Peripheral Neuropathy, Thyroxine