Indian Journal of Pharmacy and Pharmacology


HYPOTHESIS, PROGRESS AND PROBLEMS - CURRENT TREATMENTS FOR ALZHEIMER’S DISEASE: A REVIEW


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Author Details: Dinesh Raja, K.S.G. Arul Kumaran, C. Sankar, K. Selvaraj

Volume : 2

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 55

Article End Page : 61


Abstract

Alzheimer disease is one of the most complex and challenging neurodegenerative disorders. It has recently received considerable attention, especially in areas related to new treatments. Alzheimer disease is clinically characterized by progressive cognitive decline associated with impairment in activities of daily living and progressive behavioural disturbances throughout the disease course. The cholinergic system plays a vital role for learning and memory, and the memory impairment severity in Alzheimer disease is mainly associated with cholinergic dysfunction. Hence, restoration of cholinergic neurotransmission may help in treating patients with Alzheimer disease. Studies have revealed encouraging results with cholinesterase inhibitors to increase acetylcholine concentrations in the brains of patients with Alzheimer disease.