Indian Journal of Pharmacy and Pharmacology


A study of the effect of Baclofen on blood glucose level in alcohol dependence syndrome(ADS) patients at a tertiary care hospital


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Author Details: Bharadwaj G, Satyanarayana V, Shabeer D, Vishnu Vardhan G

Volume : 4

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 55

Article End Page : 61


Abstract

Background: Alcohol dependence syndrome affects an individual at physiological, behavioral, and cognitive level and include symptoms like withdrawal, tolerance, and craving. Heavy alcohol intake is often associated with many health related and social problems which poses a threat to the society. Recently Baclofen has been used to reduce the symptoms of ADS, and is shown to affect the level of blood glucose in patients receiving it.
Objective: The main objective of the study is to find out the effect of baclofen on blood glucose levels in ADS patients during therapy.
Methodology: A Prospective interventional study was designed and conducted in patients attending Psychiatry Department30 patients aged between 18 years and 60 years diagnosed with alcohol dependence syndrome (ADS) per ICD-10 criteria are enrolled in the study.
Blood glucose levels are checked at baseline, 10th day and at 20th day.
Results: Mean fasting blood glucose levels in patients was 87.1 mg/dl on day 0, 103.23mg/dl on day 1, 98.63 mg/dl on day 10 and 95.30 mg/dl on day 20.
Mean post prandial blood glucose was 125.5 mg/dl on day 0, 144.57mg/dl on day 1, 137.2 mg/dl on day 10 and 136.6 mg/dl on day 20.
Conclusion: Our study shows that Baclofen has a definite role in the levels of glucose, but the mechanism of action of depression in blood glucose levels is still unknown. Further studies are needed to confirm the long term effect of Baclofen on the blood glucose levels.

Keywords
: Baclofen, Alcohol withdrawal syndrome, FBS, PPBS