Indian Journal of Pharmacy and Pharmacology


Evaluation and comparison of hypoglycemic activity of bark and leaf of Ficus bengalensis linn. in alloxan induced diabetes in albino rats


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Author Details: Arati Chikaraddy, Yasmeen Maniyar

Volume : 4

Issue : 3

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 138

Article End Page : 142


Abstract

Objectives: Evaluation of Hypoglycemic activity of Extract of bark and leaf of Ficus bengalensis Linn.in alloxan induced diabetic albino rats and comparison with standard antihyperglycemic drug Glibenclamide.
Materials and Method: Aqueous extracts of bark and leaf of Ficus bengalensis were evaluated for hypoglycemic activity. Albino rats were divided into six groups of six-animals each. Diabetes was induced by using Alloxan monohydrate (160mg kg.b.wi.p).Control group was treated with normal saline 0.5ml; second group was treated with Glibenclamide 5mg kg as a standard antidiabetic drug. Remaining groups were treated with different doses (150 & 300mg kg.b.w) of bark and leaves of F.bengalensis for a period of 28 days. Fasting glucose level estimated by using Glucometer on days 3, 7, 14, 21 and 28.
Results: An Aqueous Extract of F.Benglensis Linn. produced significant reduction in the fasting blood glucose in diabetic rats. At the dose of 300mg/ kg of bark showed significant fall in blood. glucose level as compared to other doses of extract. Post-prandial reduction in the blood glucose levels on day 3 after 3hrs of drug administration was significant (p = 0.007) with bark 300mg as compared to other doses. This is however, highly significant (p = 0.0001) when compared with standard drug Glibenclamide.
Conclusions: The current small sample size study shows relevant antidiabetic potential for Ficus bengalensis. Further studies are required to elaborate the antidiabetic activity and mode of hypoglycemic action of Ficus bengalensis.

Keywords:
Diabetes, Ficus bengalensis, Aqueous extract, Hypoglycemia