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Indian Journal of Pharmacy and Pharmacology


Study on Antinociceptive effect of Antihistaminics in albino mice


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Author Details: Santhosh R, Shivashankaramurthy KG, Kiran Lakkol, Gokul CG

Volume : 4

Issue : 3

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 161

Article End Page : 167


Abstract

Objectives: To study the antinociceptive effect of promethazine and cetrizine in albino mice and to compare its antinociceptive effect with the standard drug morphine. Lastly to rule out the influence of sedation contributing to antinociceptive action, lorazepam a known sedative was used.
Materials and Method: A total of 84 albino mice of either sex were used in the study and were divided into two sets with each set containing 7 groups. Each group in each set contained 6 animals. Group 1 in both sets was administered with Normal saline. Group 2 in both sets was administered with Morphine. Group 3 in both sets was administered with promethazine. Group 4 in both sets was administered with promethazine. Group 5 in both sets was administered with cetrizine. Group 6 in both sets was administered with promethazine + cetirizine. Group 7 in both sets were administered with lorazepam. First set of animals were subjected to Hot plate test and second set of animals were subjected to Tail flick test.
Results: Results were evaluated by ANOVA followed by post hoc analysis. Promethazine in both tests in both doses showed significant antinociceptive effect when compared to control. Cetrizine and lorazepam on the other hand did not show significant antinociceptive effect when compared to control.
Conclusion: This study shows that promethazine has statistically significant antinociceptive activity when compared to control whereas cetrizine has no antinociceptive effect. Lorazepam did not show antinociceptive effect proving us that antinociceptive effect of promethazine is not due to its sedative properties.

Keywords:
Antinociceptive, Promethazine, Cetirizine, Morphine, Lorazepam

Doi No:-10.18231